Cox-2 Inhibitors

Overview :

The only Cox-2 inhibitor on the market as of April 2005 is celecoxib (Celebrex).

Celecoxib is indicated for treatment of rheumatoid and osteoarthritis, acute pain and the pain associated with primary dysmenorrhea. The drug is also used to reduce the number of polyps in familial adenomatous polyposis (FAP). It is not known whether there is a clinical benefit from a reduction in the number of colorectal polyps in FAP patients or whether the effects of celecoxib treatment will persist after the drug is discontinued. The efficacy and safety of celecoxib treatment in patients with FAP beyond 6 months have not been studied as of April 2005.