Summary   Summary
Featured Diseases & Conditions
Health Awareness Articles
Articles
Symptom Checker

Symptom Checker
Just click on a body part, choose your symptom and search through a world of health information.

 

Search Diseases

Search Disease

Hypercoagulation Disorders


Symptoms :

Hypercoagulation disorders may be acquired or hereditary. Some of the genetic disorders that lead to hypercoagulation are abnormal clotting factor V, variations in fibrinogen, and deficiencies in proteins C and S. Other body system diseases may also lead to these disorders, including diabetes, sickle cell anemia, congenital heart disease, lupus, thalassemia, polycythemia rubra vera, and others. Antithrombin III deficiency is a hereditary hypercoagulation disorder that affects both sexes. Symptoms include obstruction of a blood vessel by a clot (thromboembolic disease), vein inflammation (phlebitis), and ulcers of the lower parts of the legs. The role of proteins C and S is a complex one. In order for coagulation to occur, platelets (small, round fragments in the blood) help contract blood vessels to lessen blood loss and also to help plug damaged blood vessels. However, the conversion of platelets into actual clots is a complicated web involving proteins that are identified clotting factors. The factors are carried in the plasma, or liquid portion of the blood. Proteins C and S are two of the clotting factors that are present in the plasma to help regulate or activate parts of the clotting process. Protein C is considered an anticoagulant. Mutation defects in the proteins may decrease their concentrations in the blood, and may or may not affect their resulting anticoagulant activity. Factor V is an unstable clotting factor also present in plasma. Abnormal factor V resists the changes that normally occur through the influence of protein C, which can also lead to hypercoagulability. Prothrombin, a glycoprotein that converts to thrombin in the early stage of the clotting process, is affected by the presence of these proteins, as well as other clotting factors.

Diagnosis :

The diagnosis of hypercoagulation disorders is completed with a combination of physical examination, medical history, and blood tests. An accurate medical history is important to determine possible symptoms and causes of hypercoagulation disorders. There are a number of blood tests that can determine the presence or absence of proteins, clotting factors, and platelet counts in the blood. Among the tests used to detect hypercoagulation is the Antithrombin III assay. Protein C and Protein S concentrations can be diagnosed with immunoassay or plasma antigen level tests.

Prognosis :

The prognosis for patients with hypercoagulation disorders varies depending on the severity of the clotting and thrombosis. If undetected and untreated, thrombosis could lead to recurrent thrombosis and pulmonary embolism, a potentially fatal problem.




 Image Gallary
 
Search for information related to Health and wellness
Health Centers
Cardiology and HeartMen's HealthWomen's HealthMother + ChildDiabetesStressInfectious DiseaseSkinEyeCancerStop SmokingWeight ManagementSexual HealthBlood Pressure ManagementAsthmaPregnancy and Child BirthAllergyHair LossDengueCold and FluSore ThroatADHDDental & Oral HealthHigh CholesterolDepressionPolioBreast CancerFood PoisonSnoringConjunctivitisCervical CancerJaundiceGeneral HealthMigraine / HeadacheThyroidBlood SugarProstate CancerKidney DiseaseAnxietyArthritisAutismBipolar DisorderCOPDCaregivingCrohn's DiseaseEpilepsyErectile DysfunctionHealthy AgingIncontinenceMeningitisMenopauseMultiple SclerosisOsteoporosisPain ManagementParkinson's DiseaseRelationshipsSleep ManagementStomach & DigestiveOsteoarthritisPertussisOveractive BladderRheumatoid ArthritisTonsils
Search for information related to Health and wellness
 
Health Pages
blood pressure cancer cholesterol test diabetes diets erectile dysfunction hair loss health health articles healthy living heart diseases high cholesterol pregnancy reduce weight vagina weight wellness health plan sexual problems lower cholesterol heart attack women health asthma weight loss anxiety back problems disease symptoms immunization for children indian home remedies indian recipes Manage weight pathology tests stress leptospirosis over the counter male enhancement supporting abortion lumps breast natural breasts dod breast cancer when is it too late to have an abortion back pain in pregnancy low cost ivf symptoms of pre diabetes body mass index beyond dental and health february national heart month heart bio red spot on breast