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Sleeping Sickness


Overview :

Protozoa are single-celled organisms considered to be the simplest life form in the animal kingdom. The protozoa responsible for sleeping sickness are a variety that bear numerous flagella (hair-like projections from the cell that help the cell to move). These protozoa exist only on the continent of Africa. The type of protozoa causing sleeping sickness in humans is referred to as the Trypanasoma brucei complex, which can be divided further into Rhodesian (Central and East African) and Gambian (Central and West African) subspecies.

The Rhodesian variety live within antelopes in savanna and woodland areas, and they cause no problems with the antelope's health. The protozoa are then acquired by tsetse flies when they bite and suck the blood of an infected antelope or cow.

DAVID BRUCE (1855–1931)

David Bruce was born in Melbourne, Australia, on May 29, 1855, to Scottish immigrants. Bruce's family moved back to Scotland when he was five years old. Bruce attended the University of Edinburgh where he studied natural history and medicine. Following his graduation, he accepted a position working with a doctor. In 1883, Bruce married Mary Elizabeth Steele who would help him with his work throughout his life.

In 1884, Bruce began to study the disease "Malta, Mediterranean" when he and Mary were stationed in Malta with the Army Medical Service. Using a microscope, Bruce discovered that the disease was caused by a "microccus" that grew in the individual's spleen. The organism responsible for this disease was ultimately isolated by Bernhard L. F. Bang. In 1905, Bruce led a scientific team that discovered that the soldiers who contracted the disease had ingested the milk of infected goats. The disease disappeared when the soldiers quit drinking goat's milk. Many physicians began calling the disease "brucellosis" in honor of Bruce's discoveries. Bruce also conducted research in Africa where he found that the tsetse fly could infect humans, as well as animals, with the "nagana" disease. Ultimately, his work would prove that sleeping sickness was caused by the tsetse fly.

In 1903, Bruce became the director of the Royal Society's Sleeping Sickness Commission and, in 1908, he was knighted. He served as commandant of the Royal Army Medical College after he and his wife returned to England. Bruce died on November 20, 1931.

Within the tsetse fly, the protozoa cycle through several different life forms; ultimately they migrate to the salivary glands of the tsetse fly. Once the protozoa are harbored in the salivary glands, they are ready to be deposited into the bloodstream of the fly's next source of a blood meal.

Humans most likely to become infected by Rhodesian trypanosomes are people such as game wardens and visitors to game parks in East Africa, who may be bitten by a tsetse fly that has fed on game (antelope) carrying the protozoa. The Rhodesian variety of sleeping sickness causes a much more severe illness, with even greater likelihood of eventual death than the Gambian form.

The Gambian variety of Trypanosoma thrives in tropical rain forests throughout Central and West Africa; it does not infect game or cattle, and is primarily a threat to people dwelling in such areas, rarely infecting visitors.




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