Hepatitis, Drug-Induced

Symptoms :

There are three general types of drug-induced hepatitis: toxic, metabolic idiosyncrasy and immunologic idiosyncrasy. With toxic hepatitis liver damage as the result of a drug complication with hepatotoxins happens to everyone who takes that particular drug. On the other hand, hepatitis resulting from a metabolic or immunologic idiosyncrasy only happens to certain people, those predisposed to particular idiosyncrasy.

In patients with a metabolic idiosyncrasy the person metabolizes the drug differently than most people causing a harmful by-product that damages the liver. A metabolic idiosyncrasy is seen in 0.1-2% of people and it is complicated by use of alcohol.

With an immunologic idiosyncrasy the patient's body recognizes the metabolized drug by-products as foreign. This leads to the destruction of liver cells containing the by-product via the immune system resulting in hepatitis. An immunologic idiosyncrasy is seen in less than one person per 10,000 (0.01%) people and is more than twice as common in women.

The symptoms of drug-induced hepatitis are similar to viral hepatitis. Drug induced hepatitis tends to be acute. If it is not caught soon enough the damage could be permanent resulting in chronic hepatitis. Some of the common symptoms are:

• nausea
• vomiting
• headache
• anorexia
• jaundice
• clay color stools
• dark urine
• hepatomegaly

  Diagnosis :

  Diagnosis is typically made through a physical exam along with a patient history to identify any possible hepatotoxins. Blood tests are usually done as well. An increased white blood cell count is typical.

  Prognosis :

  Usually the symptoms will go away after the drug has been eliminated due to the liver repairing itself. A full recovery is typically expected unless it wasn't treated quickly resulting in more liver damage being done than normal.

  
  

  Previous

  Next